Trimebutine, a new antispasmodic in the treatment of dyspepsia.

Indigestion, flatulent dyspepsia, nausea, vomiting, abdominal pain or discomfort are among the commonest complaints in adults attending their doctor’s surgery or medical out-patient department (Switz, 1976). Investigations by x-ray or endoscopy may show a peptic ulcer, diseased gall-bladder or other lesion, but in many cases objective investigations are negative. Symptoms in these patients may be caused by disordered gastro-intestinal motility rather than a welllocalised lesion, and restoration of normal motility may alleviate symptoms. Trimebutine has been shown to have a relaxant effect on gastro-intestinal smooth muscle and a regulatory effect on contractility (Frexinos, 1971). The present study was carried out to compare the symptomatic effect of Trimebutine with placebo in patients with x-ray and endoscopically negative dyspepsia.